茶树精油凝胶治疗轻度至中度痤疮
Acne is a common skin disease caused by a combination of factors including inflammation, excessive sebum production, abnormal desquamation of the follicular epithelium and an immunological response to Propionibacterium acnes. Now, the efficacy, tolerability and acceptability of a tea tree oil gel (200 mg/g) and face wash (7 mg/g) were evaluated for the treatment of mild to moderate facial acne.
痤疮是一种常见皮肤病，由多种因素引起，包括炎症、过多的油脂分泌、毛囊上皮的异常脱屑和对痤疮丙酸杆菌的免疫反应等。现在，一研究评价了茶树精油凝胶(200 mg/g)和洁面膏(7 mg/g)治疗轻度到中度痤疮的疗效、耐受性和可接受性。
In this open-label, uncontrolled phase II pilot study, participants applied tea tree oil products to the face twice daily for 12 weeks and were assessed after 4, 8 and 12 weeks. Efficacy was determined from total numbers of facial acne lesions and the investigator global assessment (IGA) score. Tolerability was evaluated by the frequency of adverse events and the mean tolerability score determined at each visit. Product acceptability was assessed via a questionnaire at the end of the study period.
在这个开放标签的、无对照的II期试验研究中，参与者脸部使用茶树精油产品，每天两次，连续使用12周，分别于第4、8、12周之后做评估。功效由面部痤疮皮损总数和研究者总体评价(IGA)分数决定。耐受性由不良反应频率评价，平均耐受分数由每次访问决定。在研究结束阶段产品接受程度由一个问卷调查评估。
Altogether 18 participants were enrolled, of whom 14 completed the study. Mean total lesion counts were 23.7 at baseline, 17.2 at 4, 15.1 at 8 and 10.7 at 12 weeks. Total lesion counts differed significantly over time by repeated measures anova (P < 0.0001). The mean IGA score was 2.4 at baseline, 2.2 at 4, 2.0 at 8 and 1.9 at 12 weeks, which also differed significantly over time (P = 0.0094). No serious adverse events occurred and minor local tolerability events were limited to peeling, dryness and scaling, all of which resolved without intervention.
共有18人参加，其中14人完成了这项研究。平均总病灶数为：基线时23.7，4周后17.2，8周后15.1，12周后10.7。通过重复测量的方差分析（P＜0.0001），总病灶数随时间推移差异显著。平均研究者总体评价(IGA)分数：基线时2.4，4周后2.2，8周后2.0，12周后1.9，随着时间的推移同样变化很大(P = 0.0094)。无严重不良事件发生，轻微的局部耐受性事件仅限于脱皮、干燥和起屑，所有这些没有进行干预。
This study shows that the use of the tea tree oil products significantly improved mild to moderate acne and that the products were well tolerated.
这项研究表明，使用含茶树精油的产品显著改善轻度至中度痤疮，且产品具有良好的耐受性。
REFERENCE:
Australas J Dermatol. 2016 Mar 21.
痤疮是一种常见皮肤病，由多种因素引起，包括炎症、过多的油脂分泌、毛囊上皮的异常脱屑和对痤疮丙酸杆菌的免疫反应等。现在，一研究评价了茶树精油凝胶(200 mg/g)和洁面膏(7 mg/g)治疗轻度到中度痤疮的疗效、耐受性和可接受性。
In this open-label, uncontrolled phase II pilot study, participants applied tea tree oil products to the face twice daily for 12 weeks and were assessed after 4, 8 and 12 weeks. Efficacy was determined from total numbers of facial acne lesions and the investigator global assessment (IGA) score. Tolerability was evaluated by the frequency of adverse events and the mean tolerability score determined at each visit. Product acceptability was assessed via a questionnaire at the end of the study period.
在这个开放标签的、无对照的II期试验研究中，参与者脸部使用茶树精油产品，每天两次，连续使用12周，分别于第4、8、12周之后做评估。功效由面部痤疮皮损总数和研究者总体评价(IGA)分数决定。耐受性由不良反应频率评价，平均耐受分数由每次访问决定。在研究结束阶段产品接受程度由一个问卷调查评估。
Altogether 18 participants were enrolled, of whom 14 completed the study. Mean total lesion counts were 23.7 at baseline, 17.2 at 4, 15.1 at 8 and 10.7 at 12 weeks. Total lesion counts differed significantly over time by repeated measures anova (P < 0.0001). The mean IGA score was 2.4 at baseline, 2.2 at 4, 2.0 at 8 and 1.9 at 12 weeks, which also differed significantly over time (P = 0.0094). No serious adverse events occurred and minor local tolerability events were limited to peeling, dryness and scaling, all of which resolved without intervention.
共有18人参加，其中14人完成了这项研究。平均总病灶数为：基线时23.7，4周后17.2，8周后15.1，12周后10.7。通过重复测量的方差分析（P＜0.0001），总病灶数随时间推移差异显著。平均研究者总体评价(IGA)分数：基线时2.4，4周后2.2，8周后2.0，12周后1.9，随着时间的推移同样变化很大(P = 0.0094)。无严重不良事件发生，轻微的局部耐受性事件仅限于脱皮、干燥和起屑，所有这些没有进行干预。
This study shows that the use of the tea tree oil products significantly improved mild to moderate acne and that the products were well tolerated.
这项研究表明，使用含茶树精油的产品显著改善轻度至中度痤疮，且产品具有良好的耐受性。
REFERENCE:
Australas J Dermatol. 2016 Mar 21.
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