研究课题：瑞典女性咖啡消耗与DM发病的关系：18年随访回顾性研究
供稿：医疗系，Sahlgrenska大学附属医院，哥德堡， 瑞典
主要内容：目的：分析瑞典女性咖啡消耗量与DM发病的长期关联性。设计：纵向多中心回顾性研究。地点：瑞典哥德堡。对象：随机抽取1361名妇女，年龄在39-65岁，无DM或心血管病史。1979-1981年间进行问卷调查，体检和采血。主要测量结果：1999年进行第二轮问卷调查，并查瑞典医院的出院记录，明确DM发病人数。结果：共有74人新发DM。每天饮用不足2杯，3-4杯，5-6杯，＞7杯 咖啡的瑞典妇女，其DM发病率分别为475，271，202，267每10万人年。用年龄、吸烟、运动过少、教育和体重指数纠正后，以每天饮用咖啡不足2杯为对照，每天饮用4，5，6，＞7杯咖啡的妇女，其DM风险指数分别为0.55 (0.32-0.95), 0.39 (0.20-0.77)和0.48 (0.22-1.06)，再用血清胆固醇和甘油三脂进行纠正，稍微减弱了咖啡消耗量与DM发病的关联性，提示血脂可能对咖啡的效用有中间介导作用。
结论：饮用咖啡可以防止女性DM发病。
Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study.
Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson S. J Intern Med. 2004 Jan;255(1):89-95.
Department of Medicine, Sahlgrenska University Hospital/Ostra, Goteborg, Sweden.
OBJECTIVES: To examine the long-term incidence of diabetes in relation to coffee consumption in Swedish women. DESIGN: Prospective longitudinal cohort study. SETTING: City of Goteborg, Sweden. SUBJECTS: A random population sample of 1361 women, aged 39-65 years, without prior diabetes or cardiovascular disease took part in a screening study in 1979-1981 with questionnaires, physical examination and blood sampling. MAIN OUTCOME MEASURES: The development of diabetes until 1999 was identified by questionnaires in a second screening and the Swedish hospital discharge register. RESULTS: Altogether, there were 74 new cases of diabetes. The risk of developing diabetes was 475 per 100 000 person-years in women who consumed two cups of coffee or less per day, 271 in women who consumed three to four cups per day, 202 with a consumption of five to six cups per day, and 267 in drinkers of seven cups or more per day. Associated hazard ratios, after adjustment for age, smoking, low physical activity, education and body background="../images_new/bg_hei.jpg" mass index were 0.55 (0.32-0.95), 0.39 (0.20-0.77) and 0.48 (0.22-1.06) for daily consumption of three to four, five to six and seven cups or more, respectively, with a consumption of less than two per day as reference. Additional adjustment for serum cholesterol and triglycerides attenuated the relation between coffee and diabetes slightly, indicating a possible mediating effect on the effect of coffee by serum lipids. CONCLUSIONS: The findings of the present study support the hypothesis that coffee consumption protects from the development of diabetes in women.
主要内容：目的：分析瑞典女性咖啡消耗量与DM发病的长期关联性。设计：纵向多中心回顾性研究。地点：瑞典哥德堡。对象：随机抽取1361名妇女，年龄在39-65岁，无DM或心血管病史。1979-1981年间进行问卷调查，体检和采血。主要测量结果：1999年进行第二轮问卷调查，并查瑞典医院的出院记录，明确DM发病人数。结果：共有74人新发DM。每天饮用不足2杯，3-4杯，5-6杯，＞7杯 咖啡的瑞典妇女，其DM发病率分别为475，271，202，267每10万人年。用年龄、吸烟、运动过少、教育和体重指数纠正后，以每天饮用咖啡不足2杯为对照，每天饮用4，5，6，＞7杯咖啡的妇女，其DM风险指数分别为0.55 (0.32-0.95), 0.39 (0.20-0.77)和0.48 (0.22-1.06)，再用血清胆固醇和甘油三脂进行纠正，稍微减弱了咖啡消耗量与DM发病的关联性，提示血脂可能对咖啡的效用有中间介导作用。
结论：饮用咖啡可以防止女性DM发病。
Coffee and incidence of diabetes in Swedish women: a prospective 18-year follow-up study.
Rosengren A, Dotevall A, Wilhelmsen L, Thelle D, Johansson S. J Intern Med. 2004 Jan;255(1):89-95.
Department of Medicine, Sahlgrenska University Hospital/Ostra, Goteborg, Sweden.
OBJECTIVES: To examine the long-term incidence of diabetes in relation to coffee consumption in Swedish women. DESIGN: Prospective longitudinal cohort study. SETTING: City of Goteborg, Sweden. SUBJECTS: A random population sample of 1361 women, aged 39-65 years, without prior diabetes or cardiovascular disease took part in a screening study in 1979-1981 with questionnaires, physical examination and blood sampling. MAIN OUTCOME MEASURES: The development of diabetes until 1999 was identified by questionnaires in a second screening and the Swedish hospital discharge register. RESULTS: Altogether, there were 74 new cases of diabetes. The risk of developing diabetes was 475 per 100 000 person-years in women who consumed two cups of coffee or less per day, 271 in women who consumed three to four cups per day, 202 with a consumption of five to six cups per day, and 267 in drinkers of seven cups or more per day. Associated hazard ratios, after adjustment for age, smoking, low physical activity, education and body background="../images_new/bg_hei.jpg" mass index were 0.55 (0.32-0.95), 0.39 (0.20-0.77) and 0.48 (0.22-1.06) for daily consumption of three to four, five to six and seven cups or more, respectively, with a consumption of less than two per day as reference. Additional adjustment for serum cholesterol and triglycerides attenuated the relation between coffee and diabetes slightly, indicating a possible mediating effect on the effect of coffee by serum lipids. CONCLUSIONS: The findings of the present study support the hypothesis that coffee consumption protects from the development of diabetes in women.
